Arch Ophthalmol. Aug;(8) Multicenter Trial of Cryotherapy for Retinopathy of Prematurity: ophthalmological outcomes at 10 years. Cryotherapy . The most effective proven treatments for ROP are laser therapy or cryotherapy. Laser therapy “burns away” the periphery of the retina, which has no normal. are discussed. Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.’2 Cryotherapy was first used in the treatment of this condition in the.

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Some infants who develop stage III improve with no treatment and eventually develop normal vision. Some of this caution was removed in the conclusions of the 3-month interval publication. Post hoc analysis of enrollment suggests possible overrepresentation of black infants, multiple births, and dop. The disease improves and leaves no permanent damage in milder cases of ROP. The lack of reproducible, objective assessments of pretreatment staging is a limitation of the study design and may have introduced bias and variability in the data despite the efforts in the study to train and standardize classification among the investigators and centers.

This involves placing a silicone band around the eye and tightening it. October 17, ; final revision received November 9, ; accepted November 18, Patients were recruited from admissions to the participating centers, potentially introducing a bias due to their tertiary rlp and referral patterns.

These abnormal blood vessels are fragile and can leak, scarring the retina and pulling it out of position.

The very high completion rate of 5- and year follow-up examinations for the study, the development of the subjects to the point at which more sophisticated visual function tests can be done, and the time elapsed from the initial treatment have allowed the study to achieve this long-term descriptive goal. These technical and logistical limitations caused compromises in the design of the CRYO-ROP study related to recruitment and randomization, treatment, choice of outcomes to be measured, ethical factors, and statistical analysis.

Not all babies respond to ROP treatment, and the disease may get worse.

Evaluating the Cryotherapy for Retinopathy of Prematurity Study (CRYO-ROP)

The quality of the information measured, including its statistical measurement and clinical relevance; the number and quality of publications produced from the data and their subsequent citation; the development of new tools for future clinical research and patient care; and secondary trials founded on the initial results are also important measures of the influence of a clinical investigation.


However, the magnitude of the benefit of treatment was exaggerated by this design when compared with the vision outcomes.

However, at about the same time as the trial, transpupillary laser photocoagulation was introduced as a alternative treatment. At the time of the development of the CRYO-ROP study in the mid s, accumulating anecdotal experience and small case series suggested the procedure was safe and showed possible benefit, 56 but at the time of the initiation of this trial, there was no widely endorsed treatment strategy and therefore no universal screening criteria. By judicious choice of a threshold for treatment that allowed a statistically and clinically relevant improvement in outcomes, and by choosing outcome measures that were both expeditious fundus appearance and relevant visual functionthe study planners created a framework for answering the important question of treatment benefits from ablative therapy.

Stage IV — Partially detached retina. Although the exact rate of reduction in unfavorable outcomes has varied depending on the length of follow-up and type of outcome measured, the CRYO-ROP study has been very successful in demonstrating the clinically relevant benefit of treatment in both anatomical and functional outcomes.

Results of U.S. randomized clinical trial of cryotherapy for ROP (CRYO-ROP).

Nevertheless, there remain a substantial group of eyes, Asymmetrical patients assigned to the untreated control group also might suffer if treatment was beneficial. Long-term results of cryotherapy for active stages of retinopathy of prematurity.

Roop of acute proliferative retinopathy of prematurity during the past 15 years in Tenri Hospital. Other measurements of visual function also showed significant benefit in treated eyes, including contrast sensitivity and visual fields.

Results of U.S. randomized clinical trial of cryotherapy for ROP (CRYO-ROP).

The abnormal blood vessels grow toward the center of the eye instead of following their normal growth pattern along the surface of the retina.

About 14,—16, of these infants are affected by some degree of ROP. In addition, this trial led to innovations in the design and organization of randomized interventional trials that have gained wide acceptance and application in other fields.


Long-term results of CRYO-ROP have also influenced the management of affected patients throughout the remainder of childhood, including long-term surveillance for late retinal changes, refractive error, and amblyopia management. These new blood vessels are fragile and weak and can bleed, leading to retinal scarring. Get free access to newly published articles Create a personal account or sign in to: About 90 percent of all infants with ROP are in the milder category and do not need treatment.

The quality of the data obtained, the study design, and the decision to terminate enrollment early when the benefit of treatment was apparent set standards against which current and future clinical treatment trials will be measured. The choice of an anatomic outcome was appropriately expedient, allowing earlier analysis, and the benefit of treatment has remained clinically and statistically relevant in subsequent reports of visual function.

CRYO-ROP – What does CRYO-ROP stand for? The Free Dictionary

The Teller Acuity Card procedure and similar forced preferential looking grating tests, while not perfect proxies for optotype visual acuity, have contributed to the clinical treatment of amblyopia, cataracts, and other vision cyo in children in addition to ROP. The screening recommendations were implemented, and most children in neonatal units had access to treatment within a short period of time following the initial publication of the study.

The blood vessels grow gradually toward the edges of the developing retina, supplying oxygen and nutrients. It is possible that treatment top an earlier stage may also have been effective in some cases, and this cdyo the subject of a subsequent, second-generation study of laser panretinal photocoagulation for ROP, the Early Treatment for Retinopathy of Prematurity trial ETROP. Study conclusions and recommendations. The eye starts to develop at about 16 weeks of pregnancy, when the blood vessels of the retina begin to form at the optic nerve in the back of the eye.