Download Citation on ResearchGate | On Dec 31, , Martin H. Floch and others published Dispepsia (dispepsia funcional y dispepsia no ulcerosa) }. Nuestro objetivo fue evaluar los síntomas del síndrome de dispepsia funcional y su mejoría tras la erradicación del Helicobacter pylori. Se evaluaron La dispepsia funcional (DF o dispepsia no ulcerosa) se define como dolor o malestar epigástrico continuo o frecuentemente recurrente para el que no se puede.

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Provavelmente, ulcwrosa droga mais promissora e melhor estudada deste grupo de agentes redutores da sensibilidade visceral seja a fedotozina. New drugs for the treatment of functional dyspepsia. Arq Gastroenterol ;38 3: Current pharmacological treatment of functional dyspepsia is largely empirical and involves anti-secretory or prokinetic drugs.

Aims – To review recent advances in the understanding of the mechanisms involved in symptom production in functional dyspepsia, as well as the development of new drugs that may interfere with these mechanisms, which may lead to more rational and effective treatment of this clinical condition.

Method – Systematic review of papers published in English for the last 10 years. Results – New drugs that increase propulsive gastroduodenal motor activity include new benzamides similar to cisapride, CCK-A blockers, agonists of opiate receptors and motilin agonists similar to erythromycin.

Fucnional number of agents, including sumatriptan and buspirone, stimulates serotonin receptors in the myoenteric plexuses and have been shown to increase gastric accommodation to a meal. Finally, a number of new drugs that ulceroaa increase thresholds for visceral perception or modify sensations is currently under investigation. This includes agents of several groups, such as octreotide, loxiglumide, ondansetron and dlspepsia serotonin blockers, fedotozine and tricyclic antidepressant at low doses.

Conclusions – Although these new drugs may improve the pharmacological approach to the treatment of functional dyspepsia, dispepsai is funcionzl need for randomized, controlled trials to assess their efficacy. Moreover, difficulties related to the identification of the mechanisms underlying symptoms may limit the utilization of these new drugs. Intestinal diseases, drug therapy.


Efficacy of fedotozine in functional dyspepsia: Annu Rev Med ; Clarithromycin accelerates gastric emptying by inducing powerful antral contractions [abstract].

Dispepsia: Causas, Síntomas y Tratamiento –

Patterns of gastric emptying in dysmotility-like dyspepsia. Scand J Gastroenterol ; Visceral perception in health and functional dyspepsia. Crossover study of gastric distension with placebo and domperidone. Dig Dis Sci ; Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone. Dispepsai Dis Sci Camilleri M, Prather C.

Gastric motor physiology and motor disorders. Gastrointestinal and liver disease. Psychotropic medications for the treatment of functional gastrointestinal disorders. Clin Perspect Gastroenterol ;2: Effect of the kappa agonist fedotozine on perception of gastric distension in healthy humans.

Aliment Pharmacol Ther ; Influence of buspirone-induced fundus relaxation on the perception of gastric distension in man [abstract]. Diagnosing and treating patients with refractory functional gastrointestinal disorders. Ann Intern Med ; Feinle C, Read NW. Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility. Am J Physiol ; Management of nonulcer dyspepsia. N Engl J Med ; Double-blind dose-response multicenter comparison of fedotozine and placebo in treatment of nonulcer dyspepsia.

Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide.

New drugs for the treatment of functional dyspepsia

Cisapride or cimetidine in the treatment of functional dyspepsia. Hausken T, Berstad A. Wide gastric antrum in patients with non-ulcer dyspepsia: Effect of glyceryl trinitrate on antral motility and symptoms in patients with functional dyspepsia. Effects of trimebutine maleate on gastric motility in patients with gastric ulcer.

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Dispepsia: Causas, Síntomas y Tratamiento

Manometric evaluation of functional upper gut symptoms. American College of Gastroenterology. Effect of amitryptiline on symptoms, sleep and visceral perception in patients with functional dyspepsia. Symptoms and visceral funccional in severe functional and organic dyspepsia.

Gastrointestinal motor effects of erythromycin.

Motility-modifying agents and management of disorders of gastrointestinal motility. Gastroenterology ; Suppl 1: Amitryptiline improves the quality of life in patients with nonulcer dyspepsia [abstract ]. Efficacy and safety of the peripheral kappa agonist fedotozine funcoinal placebo in the treatment of functional dyspepsia. Dyspepsia, antral motor dysfunction, and gastric stasis of solids. Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients.

Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility on humans: Empiric therapy versus diagnostic tests in gastroesophageal reflux disease. A medical decision analysis. Role of impaired gastric accommodation to a meal in functional dyspepsia. A placebo-controlled trial of buspirone, a fundus relaxing drug, in functional dyspepsia: Aliment Pharmacol Ther ;9: Gut ;45 Suppl II: Tanum L, Malt UF. A new pharmacologic treatment of functional gastrointestinal disorder.

A double-blind placebo-controlled study with mianserin.

Modulation of gastric sensory and motor functions by mitrergic and alpha2-adrenergic agents in humans. Abnormal distribution of food in dysmotility-like functional dyspepsia. Relationship between upper hlcerosa symptoms and gastric distension in dysmotility-like functional dyspepsia and post-vagotomy patients.

Drug treatment of functional dyspepsia. Am J Gastroenterol ; All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Services on Demand Journal. How to cite this article.